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J Korean Soc Matern Child Health > Volume 18(2); 2014 > Article
Journal of The Korean Society of Maternal and Child Health 2014;18(2):186-195.
DOI: https://doi.org/10.21896/jksmch.2014.18.2.186    Published online July 31, 2014.
Early Life Risk Factors for Low Bone Mineral Density among Preschool Aged Children
김환지, 이혜아, 이원경, 정혜원, 박혜숙
학동 전기 아동의 낮은 골밀도에 영향을 미치는 생애초기 위험요인
김환지, 이혜아, 이원경, 정혜원, 박혜숙
To investigate the early life risk factors for low bone mineral density (BMD) in preschoolaged children.
Children aged 5 years from the Ewha Birth & Growth Cohort were followed from September2010 to November 2011. The subjects included 146 who had their BMD measured usingquantitative ultrasound densitometry. Those in the lowest quartile of BMD were classified as thelow BMD group (n=35). The early life risk factors considered were birth outcomes, advancedmaternal age (≥35 years), breast feeding, current anthropometric data, socioeconomic status, andphysical activity.
The mean BMD was 68.1±13.4 (boys 67.7±12.1, girls 71.1±20.9, p>0.05). For early liferisk factors, 17 subjects who were born to women of advanced maternal age belonged to the lowBMD group, it was a significant difference when compared with another group (37.8% vs. 15.6%,p<0.01). In addition, the proportion of low BMD increased with the average time in sedentary activities,although not significantly (p-value for trend=0.06). No associations for other risk factorswere found. In the multiple logistic analysis, advanced maternal age was independently associatedwith offspring low BMD (OR 3.7, 95% CI 1.6~8.9), even after adjusting for sex, sedentary activities,and household income. In addition, children who spent 1 hour or more a day in sedentary activitytended to be at increased risk of low BMD, but this was not significant.
Advanced maternal age is negatively associated with the BMD of their offspring inearly life. Further research is required to improve the health of the next generation, taking intoconsideration advancing maternal age.
Key Words: bone mineral density, children, cohort study, maternal age

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