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J Korean Soc Matern Child Health > Volume 20(3); 2016 > Article
Journal of The Korean Society of Maternal and Child Health 2016;20(3):196-203.
DOI: https://doi.org/10.21896/jksmch.2016.20.3.196    Published online September 30, 2016.
Infertility Treatment and Congenital Malformations
Sun Hwa Cha
Department of Obstetrics and Gynecology, Cheil General Hospital and Women's Healthcare Center, Dankook University College of Medicine, Seoul, Korea
난임 치료와 선천성 기형
단국대학교 의과대학 제일병원 산부인과
Correspondence:  Sun Hwa Cha,
Email: chaaa92@naver.com
Over the past 30 years, fertility treatments including fertility enhancing drugs, artificial insemination and in vitro fertilization (IVF) have been revolutionized. Thus, worldwide, more than 5 million children have been born after assisted reproductive technology (ART) and domestically, it was announced that 2.83% of all births in 2011 were associated with financial support from the National Supporting Program for the Subfertile (NSPS) administered by the Korean Ministry of Health and Welfare (KMHW). As more women seek for fertility treatment, there is growing concern about the safety of the methods. In this review, we aim to summarize the literature on the association between fertility treatment and congenital malformations with respect to subfertility, fertility enhancing medications, and different ART methods. To sum up, although ARTs are associated with slight increase in some malformations, it appears that the increase in congenital malformations is due less to ART methods per se than to the biological perturbations that generated the infertility necessitated ART to achieve pregnancy. And no particular organ system seems disproportionately affected. It is often instructive to remind all couples attempting pregnancy that the baseline malformation rate is 2~3%, compared with 3~4% in ART.
Key Words: congenital malformations, infertility, in vitro fertilization, artificial insemination
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