Association of the Level of Serum Uric Acid and Metabolic Syndrome in Middle-aged Women

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doi:2009.13.2.182

J Korean Soc Matern Child Health > Volume 13(2); 2009 > Article

Journal of The Korean Society of Maternal and Child Health 2009;13(2):182-194.
DOI: https://doi.org/10.21896/jksmch.2009.13.2.182 Published online July 31, 2009.

Association of the Level of Serum Uric Acid and Metabolic Syndrome in Middle-aged Women

이혜미¹, 박정한¹, 김성희², 김종연¹

¹대구가톨릭대학교
²포항공과대학교

일부 중년여성에서의 혈청요산농도와 대사증후군의 관련성

이혜미¹, 박정한¹, 김성희², 김종연¹

¹대구가톨릭대학교
²포항공과대학교

Abstract

Objectives
Hyperuricemia is known to be a risk factor for cardiovascular disease. The variables related to metabolic syndrome(MS), as well as other cardiovascular risk factors such as serum uric acid, differ according to gender. The study was performed to assess the relationship of serum uric acid (SUA) with metabolic syndrome in middle- aged healthy women and observed the patterns of those association in pre- and post- menopausal status.
Methods
The 757 women aged over 40 years who had visit for Health examination were enrolled and divided into four groups (Quartile 1:1.7~3.6 mg/dL, Quartile 2:3.7~4.2 mg/dL, Quartile 3:4.3~4.8 mg/dL, Quartile 4:4.9~7.6 mg/dL) according to their SUA level. The blood pressure, lipid profiles, fasting serum glucose, waist circumference, high sensitivity CRP and apolipoprotein were compared between the four group. The MS was defined by the modified ATP III criteria.
Results
The prevalence of MS was 16.8%. There was a positive association between SUA and component of MS excepting fasting serum glucose, respectively (p<0.001). After adjustment for covariates, the risk of women in the highest quartile of SUA (4.9~ 7.6 mg/dL) had 2.14 (95% CI: 1.16~3.97) fold increase in risk of MS as compared with those who were in the lowest quartile (1.7~3.6 mg/dL). and the same patterns were observed in pre-and post menopausal status. The association between SUA and MS observed more strangely in pre-menopausal status than post-menopausal status but interaction between SUA and menopausal status was not significant.
Conclusion
Our study suggests that SUA levels were independently associated with metabolic syndrome. Although the SUA level was in the normal range, the risk of metabolic syndrome was increased with an elevated serum uric acid level. However, because of the cross-sectional nature of our study, these findings should be confirmed in prospective cohort studies.

Key Words: "metabolic syndrome, uric acid, woman, menopause,"