서 론
대상 및 방법
1. 연구 대상
2. 평균 운동량 측정을 위한 운동 설문
- 걷기 활동(walking) MET-min/week=3.3 min× min of activity/day × days per week
- 중간정도 활동(moderate) MET-min/week=4.0 min× min of activity/day× days per week
- 격렬한 활동(vigorous) MET-min/week=8.0 min× min of activity/day × days per week
- 총 신체활동량=걷기활동 MET-min/week+중간정도 활동 MET-min/week+격렬한 활동 MET-min/week
3. 결과 변수와 공변수
4. 분석 방법
결 과
Table 1.
Table 2.
Variable | Minimally active, <3,000 MET-min (n=93) | Health enhancing, ≥3,000 MET-min (n=38) | p-value for difference |
Age (yr) | 37.5±4.0 | 37.5±4.6 | 0.947 |
AMH (ng/mL) | 2.6±2.9 | 2.4±2.1 | 0.737 |
Diminished ovarian reserve (AMH <0.5 ng/mL) | 16/87 (18.4) | 9/36 (25.0) | 0.409 |
BMI (kg/m2) | 22.2±3.3 | 22.1±2.8 | 0.847 |
Obesity (≥25kg/m2) | 17/90 (18.9) | 5/37 (13.5) | 0.469 |
Infertility longer than 1 year | 67/93 (72.0) | 30/38 (78.9) | 0.415 |
Nulliparity | 44/93 (47.3) | 19/38 (50.0) | 0.78 |
Harmful alcohol drinking | 7/88 (8.0) | 2/37 (5.4) | 0.617 |
Past smoking | 13/93 (14.0) | 3/38 (7.9) | 0.341 |
Graduate school education | 21/93 (22.6) | 6/38 (15.8) | 0.386 |
Male factor | 41/81 (50.6) | 14/32 (43.8) | 0.511 |
MET-min | 1,478.5±856.7 | 6,687.2±5,698.7 | <0.001* |
Pregnancy after IVF | 40/92 (43.5) | 11/38 (28.9) | 0.126 |
AMH, anti-Müllerian hormone; BMI, body mass index; MET, metabolic equivalent task-minutes; IVF, in vitro fertilization.
Cutoff AMH level for the definition of diminished ovarian reserve is determined based on the Bologna criteria (Ferraretti et al., 2011). Cutoff BMI level for the definition of obesity is based on the Asian criteria.
Table 3.
Variable | Relative risk (95% CI) | p-value |
Age (yr) | ||
<35 | 1.00 (reference) | - |
35-39 | 1.02 (0.48-2.14) | 0.966 |
≥40 | 0.33 (0.11-0.94) | 0.038* |
Diminished ovarian reserve (AMH <0.5 ng/mL) |
0.66 (0.24-1.84) | 0.428 |
Infertility ≥1 yr | 0.80 (0.39-1.64) | 0.549 |
Nulliparity | 1.75 (0.89-3.44) | 0.104 |
Harmful alcohol drinking | 1.10 (0.38-3.14) | 0.861 |
Past smoking | 1.54 (0.59-4.02) | 0.383 |
Graduate school education | 1.23 (0.55-2.74) | 0.610 |
Obesity | 1.07 (0.46-2.49) | 0.875 |
Male factor | 1.20 (0.61-2.36) | 0.603 |
Average activity per week | ||
Minimally active (<3,000 MET-min) | 1.00 (reference) | |
Health enhancing (≥3,000 MET-min) | 0.92 (0.44-1.93) | 0.826 |